90% of all businesses in the USA were started and successfully run by people with only a high school education or less. Business is business and I would never hire anyone who believes any different. As far as being hard to run a business, not at all. It's all in the mind set.
Bill Gates did it.
Anyone can run a business. After all, monkeys do it.
it is recommended that you have some sort of "Entrepreneurship" degree and you definitely need to know how to market!